{"id":20879,"date":"2018-05-16T15:31:00","date_gmt":"2018-05-16T15:31:00","guid":{"rendered":"https:\/\/www.he-arc.ch\/projets-recherche\/drugsens\/"},"modified":"2022-02-03T12:38:33","modified_gmt":"2022-02-03T11:38:33","slug":"drugsens","status":"publish","type":"he-arc_project","link":"https:\/\/www.he-arc.ch\/en\/projets-recherche\/drugsens\/","title":{"rendered":"DrugSens"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"context-and-challenges\">Context and challenges<\/h2>\n\n\n\n<p>In hospitals during cancer chemotherapies, patients are subjects to administration of very high doses of the therapeutic substance during several days. Ideally, drug doses should be continuously adjusted resulting in medicament blood concentrations being kept within a therapeutic range. This requires regular blood tests (typically every 15 to 30 minutes).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"objectives\">Objectives<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Development of a microfluidic system for blood sample handling towards the biosensor and subsequent washing in between measurements<\/li><li>Adaptation of biosensors for continuous blood measurements<\/li><li>Integration of the biosensors within hydrogels for filtration of unwanted blood cells during continuous measurements<\/li><li>Integrated optical detection<\/li><li>Automated system for sample measurements every 30 minutes within 24h treatment duration<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"partners-and-funding\">Partners and funding<\/h2>\n\n\n\n<p><a href=\"https:\/\/www.hevs.ch\/en\/rad-institutes\/institute-of-life-technologies\/\" target=\"_blank\" rel=\"noopener\">Institute of Life Technologies, HES-SO Valais<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.hevs.ch\/en\/pages-instituts\/institute-of-systems-engineering-1478\/\" target=\"_blank\" rel=\"noreferrer noopener\">Institute of Systems Engineering, HES-SO Valais<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/chemtech.heia-fr.ch\/EN\/presentation\/Pages\/core-competences.aspx\" target=\"_blank\" rel=\"noopener\">Institute of Chemical Technology, HES-SO Fribourg<\/a><\/p>\n\n\n\n<p>Funded by the <a href=\"https:\/\/www.hes-so.ch\/en\/homepage-hes-so-1679.html\" target=\"_blank\" rel=\"noopener\">HES-SO University of Applied Sciences Western Switzerland<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"results\">Results<\/h2>\n\n\n\n<p>We have created an autonomous system allowing to perform measurements using supramolecular bio-sensors whose fluorescence is modulated by the presence of the active chemotherapeutic substance, <em>methotrexate<\/em>.<\/p>\n\n\n\n<figure class=\"wp-block-image is-style-default\"><img decoding=\"async\" src=\"\/wp-content\/uploads\/oldsite\/projets\/DrugSens1.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"project-manager-for-he-arc-ingenierie\">Project Manager (for HE-Arc Ing\u00e9nierie)<\/h2>\n\n\n\n<div id=\"contact-card-block_619646874bb29\" class=\"contact-card is-shadowed mb-2-5 is-not-contained\">\n  <div class=\"contact-card__inner\">\n                <div class=\"contact-entry mb-1\">\n        Dr. Alexandra Homsy\n      <\/div>\n                      <div class=\"contact-entry mb-1\">\n        <a href=\"tel:+41329302553\"  class=\"simple-link contact-entry mb-1\">+41 32 930 25 53<\/a>\n      <\/div>\n                      <div class=\"contact-entry \">\n        <a href=\"mailto:alexandra.kaempfer-homsy@he-arc.ch\"  class=\"simple-link contact-entry mb-1\">Alexandra.Kaempfer-Homsy@he-arc.ch<\/a>\n      <\/div>\n            <\/div>\n<\/div>\n","protected":false},"author":16,"featured_media":15828,"template":"","he-arc_domain":[3],"he-arc_project_skill":[64],"he-arc_project_year":[38,39],"class_list":["post-20879","he-arc_project","type-he-arc_project","status-publish","has-post-thumbnail","hentry","he-arc_domain-ingenierie","he-arc_project_skill-dispositifs-medicaux","he-arc_project_year-38","he-arc_project_year-39"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>DrugSens - Haute-Ecole Arc<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.he-arc.ch\/en\/projets-recherche\/drugsens\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DrugSens - Haute-Ecole Arc\" \/>\n<meta property=\"og:description\" content=\"Context and challenges In hospitals during cancer chemotherapies, patients are subjects to administration of very high doses of the therapeutic substance during several days. 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